Scaffold | Generation | Construct Molecular Weight (KDa) | Relative Surface Charge | Relative Structure Flexibility | #Surface group (PEG) | PEG Molecular Weight (KDa) | Total PEG Molecular Weight (KDa) | %Total PEG Molecular Weight | #Surface group (non-PEG Sites) | #Surface group (OH) | #Surface group (NH2) | #Surface group (Drug) | #Surface group (Ac) | #Surface group (do3a-Gd) | #Surface group (Sulphates) | #Surface group (CNNH2) | Surface Drug | % Dose in Liver | % Dose in Urine | Volume of Distribution (mL/kg) | Half-life (hours) | Clearance (mL/h/kg) | Reference |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PAMAM | 3.0 | 8.0 | 3 | 0 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 29 | 0 | 0 | 0 | 0 | 0 | NA | 4 | NA | 115.44 | 2 | 40 | link |
PAMAM | 2.0 | 21.0 | 0 | 0 | 7 | 2.0 | 14.0 | 0.67 | 5 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | NA | 7 | 30 | NA | 6 | NA | link |
PAMAM | 2.0 | 24.0 | 0 | 0 | 3 | 5.0 | 15.0 | 0.63 | 9 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | NA | 1 | 38 | NA | 0.6 | NA | link |
PAMAM | 5.0 | 29.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 128 | 128 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 12 | NA | 2164.50 | 3 | 500 | link |
PAMAM | 3.0 | 33.0 | 0 | 0 | 24 | 1.0 | 24.0 | 0.73 | 8 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | NA | 4 | NA | 77.92 | 18 | 3 | link |
PAMAM | 3.0 | 33.0 | 0 | 0 | 9 | 2.0 | 18.0 | 0.55 | 15 | 0 | 0 | 0 | 0 | 15 | 0 | 0 | NA | 4 | NA | NA | 3 | NA | link |
PAMAM | 4.0 | 36.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 64 | 0 | 0 | 0 | 64 | 0 | 0 | 0 | NA | 4 | NA | 103.90 | 2 | 36 | link |
PAMAM | 5.0 | 41.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 128 | 0 | 28 | 0 | 81 | 0 | 0 | 0 | NA | 57 | NA | 329.00 | 19 | 12 | link |
PAMAM | 4.0 | 50.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 64 | 0 | 7 | 0 | 0 | 57 | 0 | 0 | NA | 40 | 35 | 1350.65 | 72 | 13 | link |
PAMAM | 5.0 | 52.0 | 1 | 0 | 10 | 2.0 | 20.0 | 0.38 | 118 | 0 | 44 | 0 | 74 | 0 | 0 | 0 | NA | 15 | 2 | 40.40 | 14 | 2 | link |
PAMAM | 6.0 | 58.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 256 | 256 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 35 | NA | 1443.00 | 4 | 250 | link |
PAMAM | 3.0 | 69.0 | 0 | 0 | 12 | 5.0 | 60.0 | 0.87 | 12 | 0 | 2 | 0 | 0 | 10 | 0 | 0 | NA | 8 | NA | NA | 20 | NA | link |
PAMAM | 7.0 | 117.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 512 | 512 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 7 | NA | 432.90 | 6 | 50 | link |
PAMAM | 4.0 | 162.0 | 0 | 0 | 63 | 2.0 | 126.0 | 0.78 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | NA | 7 | NA | 177.49 | 41 | 3 | link |
PAMAM | 5.0 | 284.0 | 0 | 0 | 110 | 2.0 | 220.0 | 0.77 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | NA | 7 | NA | 134.20 | 31 | 3 | link |
PAMAM | 4.0 | 334.0 | 0 | 0 | 60 | 5.0 | 300.0 | 0.9 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | NA | 6 | NA | 112.55 | 78 | 1 | link |
polyester | 1.0 | 22.0 | 0 | 3 | 2 | 10.0 | 20.0 | 0.91 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 1 | 33 | 1189.03 | 8 | 103 | link |
polyester | 2.0 | 23.0 | 0 | 2 | 4 | 5.0 | 20.0 | 0.87 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 22 | 333.33 | 11 | 21 | link |
polyester | 2.0 | 43.0 | 0 | 2 | 4 | 10.0 | 40.0 | 0.93 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 6 | 34 | 150.07 | 26 | 4 | link |
polyester | 1.0 | 44.0 | 0 | 3 | 2 | 20.0 | 40.0 | 0.91 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 20 | 219.34 | 1 | 152 | link |
polyester | 3.0 | 45.0 | 0 | 1 | 8 | 5.0 | 40.0 | 0.89 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 4 | 3 | 134.20 | 31 | 3 | link |
polyester | 3.0 | 85.0 | 0 | 1 | 8 | 10.0 | 80.0 | 0.94 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 6 | 2 | 115.44 | 40 | 2 | link |
polyester | 2.0 | 87.0 | 0 | 2 | 4 | 20.0 | 80.0 | 0.92 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 10 | 108.23 | 25 | 3 | link |
polyester | 3.0 | 160.0 | 0 | 1 | 8 | 20.0 | 160.0 | 1.0 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 7 | 144.30 | 50 | 2 | link |
polyglycerol | 2.0 | 6.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 8 | 55 | 323.23 | 16 | 14 | link |
polyglycerol | 2.0 | 9.0 | -1 | 0 | 0 | 0.0 | 0.0 | 0.0 | 16 | 10 | 0 | 0 | 0 | 0 | 6 | 0 | NA | 90 | 5 | 80.81 | 1 | 56 | link |
polyglycerol | 2.0 | 13.0 | -2 | 0 | 0 | 0.0 | 0.0 | 0.0 | 16 | 3 | 0 | 0 | 0 | 0 | 13 | 0 | NA | 76 | 1 | 92.35 | 1 | 64 | link |
polylysine | 3.0 | 2.0 | 3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 16 | 0 | 16 | 0 | 0 | 0 | 0 | 0 | NA | 5 | 8 | 280.23 | 0.1 | 1942 | link |
polylysine | 4.0 | 4.0 | 3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 32 | 0 | 0 | 0 | 0 | 0 | NA | 24 | 4 | 415.58 | 0.1 | 2880 | link |
polylysine | 4.0 | 4.0 | 3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 32 | 0 | 0 | 0 | 0 | 0 | NA | 10 | 4 | 668.11 | 0.1 | 4630 | link |
polylysine | 4.0 | 5.0 | -2 | 1 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 12 | 25 | 92.21 | 0.9 | 71 | link |
polylysine | 3.0 | 6.0 | 0 | 1 | 16 | 0.2 | 3.2 | 0.53 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 0 | 82 | 560.17 | 0.6 | 647 | link |
polylysine | 4.0 | 7.0 | -3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 0 | 0 | 0 | 0 | 32 | 0 | NA | 0 | 63 | 501.01 | 0.2 | 1736 | link |
polylysine | 4.0 | 10.0 | -3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 16 | 0 | 0 | 0 | 0 | 0 | 16 | 0 | NA | 26 | 30 | 27.27 | 0.9 | 21 | link |
polylysine | 4.0 | 11.0 | 0 | 1 | 32 | 0.2 | 6.4 | 0.58 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 0 | 80 | 386.87 | 0.7 | 383 | link |
polylysine | 3.0 | 11.0 | 0 | 0 | 8 | 0.57 | 4.56 | 0.41 | 8 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | MTX | 1 | 56 | 63.92 | 0.1 | 443 | link |
polylysine | 4.0 | 13.0 | 2 | 1 | 16 | 0.57 | 9.12 | 0.7 | 16 | 0 | 16 | 0 | 0 | 0 | 0 | 0 | NA | 3 | 74 | 30.74 | 0.1 | 213 | link |
polylysine | 4.0 | 14.0 | 0 | 1 | 16 | 0.57 | 9.12 | 0.65 | 16 | 0 | 0 | 0 | 16 | 0 | 0 | 0 | NA | 0.3 | 72 | 206.78 | 0.1 | 1433 | link |
polylysine | 4.0 | 14.0 | -3 | 1 | 0 | 0.0 | 0.0 | 0.0 | 32 | 0 | 0 | 0 | 0 | 0 | 32 | 0 | NA | 49 | 3 | 34.63 | 1 | 24 | link |
polylysine | 3.0 | 15.0 | 0 | 0 | 8 | 1.0 | 8.0 | 0.53 | 8 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | MTX | 1 | 64 | 95.24 | 0.2 | 330 | link |
polylysine | 4.0 | 21.0 | 0 | 0 | 16 | 0.57 | 9.12 | 0.43 | 16 | 0 | 0 | 16 | 0 | 0 | 0 | 0 | MTX | 1 | 29 | 99.86 | 0.4 | 173 | link |
polylysine | 4.0 | 22.0 | 0 | 0 | 32 | 0.57 | 18.24 | 0.83 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 33 | 181.82 | 14 | 9 | link |
polylysine | 4.0 | 22.0 | 0 | 1 | 32 | 0.57 | 18.24 | 0.83 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 2 | 43 | 245.31 | 10 | 17 | link |
polylysine | 5.0 | 27.0 | 2 | 1 | 18 | 1.0 | 18.0 | 0.67 | 55 | 0 | 55 | 0 | 0 | 0 | 0 | 0 | NA | 5 | 24 | 86.58 | 30 | 2 | link |
polylysine | 4.0 | 30.0 | 0 | 0 | 16 | 1.0 | 16.0 | 0.53 | 16 | 0 | 0 | 16 | 0 | 0 | 0 | 0 | MTX | 7 | 24 | 151.52 | 21 | 5 | link |
polylysine | 5.0 | 31.0 | 1 | 1 | 18 | 1.0 | 18.0 | 0.58 | 46 | 0 | 23 | 0 | 0 | 0 | 0 | 23 | NA | 3 | 16 | 108.23 | 25 | 3 | link |
polylysine | 3.0 | 34.0 | 0 | 1 | 16 | 2.0 | 32.0 | 0.94 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 4 | 26 | 103.90 | 24 | 3 | link |
polylysine | 5.0 | 36.0 | 1 | 1 | 18 | 1.0 | 18.0 | 0.5 | 46 | 0 | 23 | 15 | 0 | 0 | 0 | 8 | dox | 5 | 13 | 101.01 | 35 | 2 | link |
polylysine | 5.0 | 41.0 | 2 | 1 | 28 | 1.0 | 28.0 | 0.68 | 36 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | NA | 37 | 4 | 585.86 | 29 | 14 | link |
polylysine | 5.0 | 42.0 | 0 | 0 | 32 | 0.57 | 18.24 | 0.43 | 32 | 0 | 0 | 32 | 0 | 0 | 0 | 0 | MTX | 10 | 2 | 173.16 | 24 | 5 | link |
polylysine | 5.0 | 45.0 | 1 | 1 | 28 | 1.0 | 28.0 | 0.62 | 36 | 0 | 16 | 0 | 0 | 0 | 0 | 20 | NA | 4 | 4 | 95.24 | 22 | 3 | link |
polylysine | 4.0 | 47.0 | 0 | 0 | 16 | 2.3 | 36.8 | 0.78 | 16 | 0 | 0 | 16 | 0 | 0 | 0 | 0 | MTX | 10 | 8 | 98.12 | 34 | 2 | link |
polylysine | 5.0 | 48.0 | 0 | 0 | 64 | 0.57 | 36.48 | 0.76 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 8 | 6 | 53.39 | 37 | 1 | link |
polylysine | 5.0 | 53.0 | 1 | 1 | 28 | 1.0 | 28.0 | 0.53 | 36 | 0 | 16 | 15 | 0 | 0 | 0 | 5 | dox | 9 | 3 | 98.12 | 34 | 2 | link |
polylysine | 5.0 | 56.0 | 0 | 1 | 30 | 1.0 | 30.0 | 0.54 | 34 | 0 | 4 | 15 | 0 | 0 | 0 | 15 | dox | NA | NA | 73.59 | 51 | 1 | link |
polylysine | 5.0 | 59.0 | 0 | 0 | 32 | 1.0 | 32.0 | 0.54 | 32 | 0 | 0 | 32 | 0 | 0 | 0 | 0 | MTX | 12 | 1 | 147.19 | 51 | 2 | link |
polylysine | 5.0 | 64.0 | -1 | 1 | 32 | 1.0 | 32.0 | 0.5 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 16 | 16 | 142.86 | 33 | 3 | link |
polylysine | 5.0 | 64.0 | -1 | 0 | 32 | 1.0 | 32.0 | 0.5 | 32 | 0 | 6 | 26 | 0 | 0 | 0 | 0 | MTX | 52 | 2 | 34.63 | 1 | 24 | link |
polylysine | 5.0 | 64.0 | 0 | 0 | 32 | 1.0 | 32.0 | 0.5 | 32 | 0 | 6 | 26 | 0 | 0 | 0 | 0 | MTX | 8 | 9 | 75.04 | 26 | 2 | link |
polylysine | 4.0 | 68.0 | 0 | 1 | 32 | 2.0 | 64.0 | 0.94 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | 9 | 3 | 108.23 | 75 | 1 | link |
polylysine | 5.0 | 68.0 | -1 | 1 | 32 | 1.0 | 32.0 | 0.47 | 32 | 0 | 8 | 24 | 0 | 0 | 0 | 0 | MTX | 85 | 2 | 28.14 | 0.3 | 65 | link |
polylysine | 5.0 | 71.0 | 0 | 1 | 32 | 1.0 | 32.0 | 0.45 | 32 | 0 | 4 | 28 | 0 | 0 | 0 | 0 | MTX | 10 | 14 | 95.24 | 33 | 2 | link |
Triazine | 2.0 | 11.0 | 0 | 0 | 14 | 0.6 | 8.4 | 0.76 | 10 | 8 | 2 | 0 | 0 | 0 | 0 | 0 | NA | 16 | 16 | 190.91 | 27 | 4.9 | link |
Triazine | 2.0 | 30.0 | 0 | 0 | 13 | 2.0 | 26.0 | 0.87 | 11 | 8 | 3 | 0 | 0 | 0 | 0 | 0 | NA | 12 | 10 | 167.53 | 43 | 2.7 | link |
Triazine | 2.0 | 34.0 | 0 | 0 | 7 | 2.0 | 13.0 | 0.38 | 18 | 0 | 6 | 12 | 0 | 0 | 0 | 0 | pac | 10 | 41 | 173.16 | 20 | 6 | link |
Triazine | 2.0 | 37.0 | 0 | 0 | 8 | 2.0 | 16.0 | 0.43 | 16 | 0 | 4 | 12 | 0 | 0 | 0 | 0 | pac | 22 | 55 | 246.75 | 19 | 9 | link |
Triazine | 2.0 | 39.0 | 0 | 0 | 9 | 2.0 | 18.0 | 0.46 | 15 | 0 | 3 | 12 | 0 | 0 | 0 | 0 | pac | 11 | 35 | 303.03 | 15 | 14 | link |
Triazine | 2.0 | 61.0 | 0 | 0 | 7 | 5.0 | 32.5 | 0.53 | 18 | 0 | 0 | 16 | 0 | 0 | 0 | 0 | pac | 20 | 5 | 76.77 | 38 | 1.4 | link |
Triazine | 2.0 | 73.0 | 0 | 0 | 10 | 5.0 | 50.0 | 0.68 | 14 | 8 | 6 | 0 | 0 | 0 | 0 | 0 | NA | 10 | 9 | 144.30 | 100 | 1 | link |