Result

Index Chain Wild Position Mutant Chothia Distance(Å) Predicted (ΔΔGaffinity) Outcome
1 A E 57 A none 3.96 -0.04 decreased affinity
2 A E 57 C none 3.96 -0.38 decreased affinity
3 A E 57 D none 3.96 0.03 increased affinity
4 A E 57 F none 3.96 -0.4 decreased affinity
5 A E 57 G none 3.96 -0.07 decreased affinity
6 A E 57 H none 3.96 -0.24 decreased affinity
7 A E 57 I none 3.96 -0.15 decreased affinity
8 A E 57 K none 3.96 -0.12 decreased affinity
9 A E 57 L none 3.96 -0.11 decreased affinity
10 A E 57 M none 3.96 -0.13 decreased affinity
11 A E 57 N none 3.96 -0.17 decreased affinity
12 A E 57 P none 3.96 -0.08 decreased affinity
13 A E 57 Q none 3.96 -0.09 decreased affinity
14 A E 57 R none 3.96 -0.38 decreased affinity
15 A E 57 S none 3.96 -0.11 decreased affinity
16 A E 57 T none 3.96 -0.19 decreased affinity
17 A E 57 V none 3.96 -0.05 decreased affinity
18 A E 57 W none 3.96 -0.4 decreased affinity
19 A E 57 Y none 3.96 -0.2 decreased affinity
20 A E 58 A none 3.44 -0.11 decreased affinity
21 A E 58 C none 3.44 -0.53 decreased affinity
22 A E 58 D none 3.44 0.01 increased affinity
23 A E 58 F none 3.44 -0.42 decreased affinity
24 A E 58 G none 3.44 -0.16 decreased affinity
25 A E 58 H none 3.44 -0.14 decreased affinity
26 A E 58 I none 3.44 -0.17 decreased affinity
27 A E 58 K none 3.44 -0.07 decreased affinity
28 A E 58 L none 3.44 -0.1 decreased affinity
29 A E 58 M none 3.44 -0.18 decreased affinity
30 A E 58 N none 3.44 -0.12 decreased affinity
31 A E 58 P none 3.44 -0.2 decreased affinity
32 A E 58 Q none 3.44 -0.14 decreased affinity
33 A E 58 R none 3.44 -0.46 decreased affinity
34 A E 58 S none 3.44 -0.11 decreased affinity
35 A E 58 T none 3.44 -0.11 decreased affinity
36 A E 58 V none 3.44 -0.05 decreased affinity
37 A E 58 W none 3.44 -0.38 decreased affinity
38 A E 58 Y none 3.44 -0.13 decreased affinity
39 A P 59 A none 3.29 -1.1 decreased affinity
40 A P 59 C none 3.29 -0.13 decreased affinity
41 A P 59 D none 3.29 -0.15 decreased affinity
42 A P 59 E none 3.29 -0.19 decreased affinity
43 A P 59 F none 3.29 0.13 increased affinity
44 A P 59 G none 3.29 -1.51 decreased affinity
45 A P 59 H none 3.29 0.05 increased affinity
46 A P 59 I none 3.29 -0.96 decreased affinity
47 A P 59 K none 3.29 -0.46 decreased affinity
48 A P 59 L none 3.29 -0.84 decreased affinity
49 A P 59 M none 3.29 -1.03 decreased affinity
50 A P 59 N none 3.29 -0.25 decreased affinity
51 A P 59 Q none 3.29 -0.04 decreased affinity
52 A P 59 R none 3.29 1.42 increased affinity
53 A P 59 S none 3.29 0.02 increased affinity
54 A P 59 T none 3.29 -0.08 decreased affinity
55 A P 59 V none 3.29 -0.56 decreased affinity
56 A P 59 W none 3.29 1.24 increased affinity
57 A P 59 Y none 3.29 0.01 increased affinity
58 A G 60 A none 2.8 -0.12 decreased affinity
59 A G 60 C none 2.8 0.26 increased affinity
60 A G 60 D none 2.8 0.44 increased affinity
61 A G 60 E none 2.8 0.82 increased affinity
62 A G 60 F none 2.8 0.21 increased affinity
63 A G 60 H none 2.8 0.44 increased affinity
64 A G 60 I none 2.8 0.02 increased affinity
65 A G 60 K none 2.8 0.46 increased affinity
66 A G 60 L none 2.8 0.26 increased affinity
67 A G 60 M none 2.8 0.18 increased affinity
68 A G 60 N none 2.8 0.42 increased affinity
69 A G 60 P none 2.8 -0.9 decreased affinity
70 A G 60 Q none 2.8 0.31 increased affinity
71 A G 60 R none 2.8 0.63 increased affinity
72 A G 60 S none 2.8 0.42 increased affinity
73 A G 60 T none 2.8 0.5 increased affinity
74 A G 60 V none 2.8 0.09 increased affinity
75 A G 60 W none 2.8 1.03 increased affinity
76 A G 60 Y none 2.8 0.24 increased affinity
77 A S 61 A none 2.64 -0.56 decreased affinity
78 A S 61 C none 2.64 -0.44 decreased affinity
79 A S 61 D none 2.64 -0.17 decreased affinity
80 A S 61 E none 2.64 0.49 increased affinity
81 A S 61 F none 2.64 0.9 increased affinity
82 A S 61 G none 2.64 -1.28 decreased affinity
83 A S 61 H none 2.64 1.04 increased affinity
84 A S 61 I none 2.64 -0.6 decreased affinity
85 A S 61 K none 2.64 0.28 increased affinity
86 A S 61 L none 2.64 -0.66 decreased affinity
87 A S 61 M none 2.64 -0.23 decreased affinity
88 A S 61 N none 2.64 0.2 increased affinity
89 A S 61 P none 2.64 -1.23 decreased affinity
90 A S 61 Q none 2.64 0.38 increased affinity
91 A S 61 R none 2.64 1.42 increased affinity
92 A S 61 T none 2.64 -0.4 decreased affinity
93 A S 61 V none 2.64 -0.98 decreased affinity
94 A S 61 W none 2.64 1.68 increased affinity
95 A S 61 Y none 2.64 1.1 increased affinity
96 A E 62 A none 2.45 -1.49 decreased affinity
97 A E 62 C none 2.45 -1.57 decreased affinity
98 A E 62 D none 2.45 -0.54 decreased affinity
99 A E 62 F none 2.45 -1.36 decreased affinity
100 A E 62 G none 2.45 -1.61 decreased affinity
101 A E 62 H none 2.45 -1.55 decreased affinity
102 A E 62 I none 2.45 -1.47 decreased affinity
103 A E 62 K none 2.45 -1.48 decreased affinity
104 A E 62 L none 2.45 -1.56 decreased affinity
105 A E 62 M none 2.45 -1.6 decreased affinity
106 A E 62 N none 2.45 -1.46 decreased affinity
107 A E 62 P none 2.45 -1.34 decreased affinity
108 A E 62 Q none 2.45 -1.29 decreased affinity
109 A E 62 R none 2.45 -1.67 decreased affinity
110 A E 62 S none 2.45 -1.46 decreased affinity
111 A E 62 T none 2.45 -1.21 decreased affinity
112 A E 62 V none 2.45 -1.25 decreased affinity
113 A E 62 W none 2.45 -0.99 decreased affinity
114 A E 62 Y none 2.45 -1.45 decreased affinity
115 A T 63 A none 5.68 -0.63 decreased affinity
116 A T 63 C none 5.68 -0.52 decreased affinity
117 A T 63 D none 5.68 -0.28 decreased affinity
118 A T 63 E none 5.68 -0.32 decreased affinity
119 A T 63 F none 5.68 -0.66 decreased affinity
120 A T 63 G none 5.68 -0.76 decreased affinity
121 A T 63 H none 5.68 -0.29 decreased affinity
122 A T 63 I none 5.68 -0.43 decreased affinity
123 A T 63 K none 5.68 -0.17 decreased affinity
124 A T 63 L none 5.68 -0.4 decreased affinity
125 A T 63 M none 5.68 -0.72 decreased affinity
126 A T 63 N none 5.68 -0.04 decreased affinity
127 A T 63 P none 5.68 -0.77 decreased affinity
128 A T 63 Q none 5.68 -0.34 decreased affinity
129 A T 63 R none 5.68 -0.58 decreased affinity
130 A T 63 S none 5.68 -0.25 decreased affinity
131 A T 63 V none 5.68 -0.47 decreased affinity
132 A T 63 W none 5.68 -0.58 decreased affinity
133 A T 63 Y none 5.68 -0.51 decreased affinity
134 A S 64 A none 2.86 -0.06 decreased affinity
135 A S 64 C none 2.86 -0.26 decreased affinity
136 A S 64 D none 2.86 0.3 increased affinity
137 A S 64 E none 2.86 0.05 increased affinity
138 A S 64 F none 2.86 -0.11 decreased affinity
139 A S 64 G none 2.86 -0.02 decreased affinity
140 A S 64 H none 2.86 -0.36 decreased affinity
141 A S 64 I none 2.86 -0.09 decreased affinity
142 A S 64 K none 2.86 -0.04 decreased affinity
143 A S 64 L none 2.86 -0.21 decreased affinity
144 A S 64 M none 2.86 -0.2 decreased affinity
145 A S 64 N none 2.86 -0.04 decreased affinity
146 A S 64 P none 2.86 -0.13 decreased affinity
147 A S 64 Q none 2.86 0.11 increased affinity
148 A S 64 R none 2.86 -0.14 decreased affinity
149 A S 64 T none 2.86 0.03 increased affinity
150 A S 64 V none 2.86 -0.02 decreased affinity
151 A S 64 W none 2.86 -0.12 decreased affinity
152 A S 64 Y none 2.86 -0.18 decreased affinity
153 A D 65 A none 2.32 -1.3 decreased affinity
154 A D 65 C none 2.32 -1.2 decreased affinity
155 A D 65 E none 2.32 -0.33 decreased affinity
156 A D 65 F none 2.32 -0.66 decreased affinity
157 A D 65 G none 2.32 -1.66 decreased affinity
158 A D 65 H none 2.32 -0.25 decreased affinity
159 A D 65 I none 2.32 -1.24 decreased affinity
160 A D 65 K none 2.32 -1.47 decreased affinity
161 A D 65 L none 2.32 -1.35 decreased affinity
162 A D 65 M none 2.32 -1.29 decreased affinity
163 A D 65 N none 2.32 -0.33 decreased affinity
164 A D 65 P none 2.32 -1.17 decreased affinity
165 A D 65 Q none 2.32 -0.95 decreased affinity
166 A D 65 R none 2.32 -0.18 decreased affinity
167 A D 65 S none 2.32 -1.08 decreased affinity
168 A D 65 T none 2.32 -0.17 decreased affinity
169 A D 65 V none 2.32 -0.97 decreased affinity
170 A D 65 W none 2.32 0.46 increased affinity
171 A D 65 Y none 2.32 -0.71 decreased affinity
172 A A 66 C none 3.32 0.06 increased affinity
173 A A 66 D none 3.32 0.09 increased affinity
174 A A 66 E none 3.32 0.23 increased affinity
175 A A 66 F none 3.32 -0.04 decreased affinity
176 A A 66 G none 3.32 -0.2 decreased affinity
177 A A 66 H none 3.32 -0.19 decreased affinity
178 A A 66 I none 3.32 -0.02 decreased affinity
179 A A 66 K none 3.32 -0.01 decreased affinity
180 A A 66 L none 3.32 -0.05 decreased affinity
181 A A 66 M none 3.32 -0.16 decreased affinity
182 A A 66 N none 3.32 -0.06 decreased affinity
183 A A 66 P none 3.32 -0.42 decreased affinity
184 A A 66 Q none 3.32 -0.09 decreased affinity
185 A A 66 R none 3.32 -0.07 decreased affinity
186 A A 66 S none 3.32 0.24 increased affinity
187 A A 66 T none 3.32 0.03 increased affinity
188 A A 66 V none 3.32 -0.15 decreased affinity
189 A A 66 W none 3.32 -0.08 decreased affinity
190 A A 66 Y none 3.32 -0.08 decreased affinity
191 A K 67 A none 2.64 -1.2 decreased affinity
192 A K 67 C none 2.64 -1.23 decreased affinity
193 A K 67 D none 2.64 -0.97 decreased affinity
194 A K 67 E none 2.64 -1.04 decreased affinity
195 A K 67 F none 2.64 -1.1 decreased affinity
196 A K 67 G none 2.64 -1.3 decreased affinity
197 A K 67 H none 2.64 -0.84 decreased affinity
198 A K 67 I none 2.64 -0.96 decreased affinity
199 A K 67 L none 2.64 -1.11 decreased affinity
200 A K 67 M none 2.64 -1.2 decreased affinity
201 A K 67 N none 2.64 -0.98 decreased affinity
202 A K 67 P none 2.64 -1.16 decreased affinity
203 A K 67 Q none 2.64 -1.13 decreased affinity
204 A K 67 R none 2.64 -0.92 decreased affinity
205 A K 67 S none 2.64 -1.18 decreased affinity
206 A K 67 T none 2.64 -1.04 decreased affinity
207 A K 67 V none 2.64 -1.23 decreased affinity
208 A K 67 W none 2.64 -1.18 decreased affinity
209 A K 67 Y none 2.64 -0.66 decreased affinity
210 A S 68 A none 4.15 -0.12 decreased affinity
211 A S 68 C none 4.15 -0.28 decreased affinity
212 A S 68 D none 4.15 -0.02 decreased affinity
213 A S 68 E none 4.15 0.01 increased affinity
214 A S 68 F none 4.15 -0.2 decreased affinity
215 A S 68 G none 4.15 -0.11 decreased affinity
216 A S 68 H none 4.15 -0.3 decreased affinity
217 A S 68 I none 4.15 -0.15 decreased affinity
218 A S 68 K none 4.15 -0.08 decreased affinity
219 A S 68 L none 4.15 -0.21 decreased affinity
220 A S 68 M none 4.15 -0.39 decreased affinity
221 A S 68 N none 4.15 -0.1 decreased affinity
222 A S 68 P none 4.15 -0.2 decreased affinity
223 A S 68 Q none 4.15 -0.1 decreased affinity
224 A S 68 R none 4.15 -0.27 decreased affinity
225 A S 68 T none 4.15 -0.09 decreased affinity
226 A S 68 V none 4.15 -0.11 decreased affinity
227 A S 68 W none 4.15 -0.14 decreased affinity
228 A S 68 Y none 4.15 -0.25 decreased affinity
229 H K 100 A H100(CDR-H3) 2.72 -1.12 decreased affinity
230 H K 100 C H100(CDR-H3) 2.72 -1.23 decreased affinity
231 H K 100 D H100(CDR-H3) 2.72 -0.72 decreased affinity
232 H K 100 E H100(CDR-H3) 2.72 -0.7 decreased affinity
233 H K 100 F H100(CDR-H3) 2.72 -0.82 decreased affinity
234 H K 100 G H100(CDR-H3) 2.72 -1.34 decreased affinity
235 H K 100 H H100(CDR-H3) 2.72 -0.7 decreased affinity
236 H K 100 I H100(CDR-H3) 2.72 -0.76 decreased affinity
237 H K 100 L H100(CDR-H3) 2.72 -0.82 decreased affinity
238 H K 100 M H100(CDR-H3) 2.72 -0.78 decreased affinity
239 H K 100 N H100(CDR-H3) 2.72 -0.42 decreased affinity
240 H K 100 P H100(CDR-H3) 2.72 -1.14 decreased affinity
241 H K 100 Q H100(CDR-H3) 2.72 -0.96 decreased affinity
242 H K 100 R H100(CDR-H3) 2.72 -0.84 decreased affinity
243 H K 100 S H100(CDR-H3) 2.72 -0.68 decreased affinity
244 H K 100 T H100(CDR-H3) 2.72 -0.38 decreased affinity
245 H K 100 V H100(CDR-H3) 2.72 -0.71 decreased affinity
246 H K 100 W H100(CDR-H3) 2.72 -0.88 decreased affinity
247 H K 100 Y H100(CDR-H3) 2.72 -0.27 decreased affinity
248 H G 100A A H100A(CDR-H3) 2.93 -0.46 decreased affinity
249 H G 100A C H100A(CDR-H3) 2.93 0.46 increased affinity
250 H G 100A D H100A(CDR-H3) 2.93 1.42 increased affinity
251 H G 100A E H100A(CDR-H3) 2.93 2.54 increased affinity
252 H G 100A F H100A(CDR-H3) 2.93 2.63 increased affinity
253 H G 100A H H100A(CDR-H3) 2.93 2.65 increased affinity
254 H G 100A I H100A(CDR-H3) 2.93 1.28 increased affinity
255 H G 100A K H100A(CDR-H3) 2.93 2.58 increased affinity
256 H G 100A L H100A(CDR-H3) 2.93 1.13 increased affinity
257 H G 100A M H100A(CDR-H3) 2.93 1.32 increased affinity
258 H G 100A N H100A(CDR-H3) 2.93 1.51 increased affinity
259 H G 100A P H100A(CDR-H3) 2.93 0.44 increased affinity
260 H G 100A Q H100A(CDR-H3) 2.93 2.17 increased affinity
261 H G 100A R H100A(CDR-H3) 2.93 2.8 increased affinity
262 H G 100A S H100A(CDR-H3) 2.93 0.66 increased affinity
263 H G 100A T H100A(CDR-H3) 2.93 1.09 increased affinity
264 H G 100A V H100A(CDR-H3) 2.93 -0.66 decreased affinity
265 H G 100A W H100A(CDR-H3) 2.93 3.21 increased affinity
266 H G 100A Y H100A(CDR-H3) 2.93 2.51 increased affinity
267 H G 100B A H100B(CDR-H3) 4.3 -0.53 decreased affinity
268 H G 100B C H100B(CDR-H3) 4.3 0.94 increased affinity
269 H G 100B D H100B(CDR-H3) 4.3 1.74 increased affinity
270 H G 100B E H100B(CDR-H3) 4.3 1.83 increased affinity
271 H G 100B F H100B(CDR-H3) 4.3 2.63 increased affinity
272 H G 100B H H100B(CDR-H3) 4.3 2.84 increased affinity
273 H G 100B I H100B(CDR-H3) 4.3 1.25 increased affinity
274 H G 100B K H100B(CDR-H3) 4.3 1.86 increased affinity
275 H G 100B L H100B(CDR-H3) 4.3 0.96 increased affinity
276 H G 100B M H100B(CDR-H3) 4.3 1.62 increased affinity
277 H G 100B N H100B(CDR-H3) 4.3 1.88 increased affinity
278 H G 100B P H100B(CDR-H3) 4.3 0.8 increased affinity
279 H G 100B Q H100B(CDR-H3) 4.3 2.28 increased affinity
280 H G 100B R H100B(CDR-H3) 4.3 3.32 increased affinity
281 H G 100B S H100B(CDR-H3) 4.3 1.0 increased affinity
282 H G 100B T H100B(CDR-H3) 4.3 1.55 increased affinity
283 H G 100B V H100B(CDR-H3) 4.3 1.13 increased affinity
284 H G 100B W H100B(CDR-H3) 4.3 3.18 increased affinity
285 H G 100B Y H100B(CDR-H3) 4.3 3.28 increased affinity
286 H N 31 A H31(CDR-H1) 4.85 -0.18 decreased affinity
287 H N 31 C H31(CDR-H1) 4.85 -0.37 decreased affinity
288 H N 31 D H31(CDR-H1) 4.85 0.06 increased affinity
289 H N 31 E H31(CDR-H1) 4.85 0.04 increased affinity
290 H N 31 F H31(CDR-H1) 4.85 0.01 increased affinity
291 H N 31 G H31(CDR-H1) 4.85 -0.18 decreased affinity
292 H N 31 H H31(CDR-H1) 4.85 -0.04 decreased affinity
293 H N 31 I H31(CDR-H1) 4.85 -0.04 decreased affinity
294 H N 31 K H31(CDR-H1) 4.85 -0.15 decreased affinity
295 H N 31 L H31(CDR-H1) 4.85 0.01 increased affinity
296 H N 31 M H31(CDR-H1) 4.85 -0.3 decreased affinity
297 H N 31 P H31(CDR-H1) 4.85 -0.1 decreased affinity
298 H N 31 Q H31(CDR-H1) 4.85 -0.13 decreased affinity
299 H N 31 R H31(CDR-H1) 4.85 -0.12 decreased affinity
300 H N 31 S H31(CDR-H1) 4.85 0.08 increased affinity
301 H N 31 T H31(CDR-H1) 4.85 -0.05 decreased affinity
302 H N 31 V H31(CDR-H1) 4.85 0.02 increased affinity
303 H N 31 W H31(CDR-H1) 4.85 0.0 increased affinity
304 H N 31 Y H31(CDR-H1) 4.85 0.01 increased affinity
305 H W 33 A H33(HFR2) 2.83 -2.16 decreased affinity
306 H W 33 C H33(HFR2) 2.83 -2.0 decreased affinity
307 H W 33 D H33(HFR2) 2.83 -1.85 decreased affinity
308 H W 33 E H33(HFR2) 2.83 -1.88 decreased affinity
309 H W 33 F H33(HFR2) 2.83 -1.58 decreased affinity
310 H W 33 G H33(HFR2) 2.83 -2.05 decreased affinity
311 H W 33 H H33(HFR2) 2.83 -1.67 decreased affinity
312 H W 33 I H33(HFR2) 2.83 -2.13 decreased affinity
313 H W 33 K H33(HFR2) 2.83 -1.88 decreased affinity
314 H W 33 L H33(HFR2) 2.83 -2.08 decreased affinity
315 H W 33 M H33(HFR2) 2.83 -2.1 decreased affinity
316 H W 33 N H33(HFR2) 2.83 -1.8 decreased affinity
317 H W 33 P H33(HFR2) 2.83 -2.16 decreased affinity
318 H W 33 Q H33(HFR2) 2.83 -1.9 decreased affinity
319 H W 33 R H33(HFR2) 2.83 -1.19 decreased affinity
320 H W 33 S H33(HFR2) 2.83 -1.95 decreased affinity
321 H W 33 T H33(HFR2) 2.83 -1.95 decreased affinity
322 H W 33 V H33(HFR2) 2.83 -2.16 decreased affinity
323 H W 33 Y H33(HFR2) 2.83 0.06 increased affinity
324 H I 50 A H50(HFR2) 5.49 -1.03 decreased affinity
325 H I 50 C H50(HFR2) 5.49 -0.77 decreased affinity
326 H I 50 D H50(HFR2) 5.49 -0.16 decreased affinity
327 H I 50 E H50(HFR2) 5.49 0.45 increased affinity
328 H I 50 F H50(HFR2) 5.49 0.45 increased affinity
329 H I 50 G H50(HFR2) 5.49 -0.96 decreased affinity
330 H I 50 H H50(HFR2) 5.49 0.11 increased affinity
331 H I 50 K H50(HFR2) 5.49 0.06 increased affinity
332 H I 50 L H50(HFR2) 5.49 -0.79 decreased affinity
333 H I 50 M H50(HFR2) 5.49 -0.49 decreased affinity
334 H I 50 N H50(HFR2) 5.49 -0.17 decreased affinity
335 H I 50 P H50(HFR2) 5.49 -0.98 decreased affinity
336 H I 50 Q H50(HFR2) 5.49 -0.19 decreased affinity
337 H I 50 R H50(HFR2) 5.49 1.02 increased affinity
338 H I 50 S H50(HFR2) 5.49 -0.58 decreased affinity
339 H I 50 T H50(HFR2) 5.49 -0.47 decreased affinity
340 H I 50 V H50(HFR2) 5.49 -0.28 decreased affinity
341 H I 50 W H50(HFR2) 5.49 1.18 increased affinity
342 H I 50 Y H50(HFR2) 5.49 1.51 increased affinity
343 H Y 52 A H52(CDR-H2) 3.38 -1.2 decreased affinity
344 H Y 52 C H52(CDR-H2) 3.38 -1.04 decreased affinity
345 H Y 52 D H52(CDR-H2) 3.38 -0.77 decreased affinity
346 H Y 52 E H52(CDR-H2) 3.38 -0.77 decreased affinity
347 H Y 52 F H52(CDR-H2) 3.38 -0.42 decreased affinity
348 H Y 52 G H52(CDR-H2) 3.38 -1.26 decreased affinity
349 H Y 52 H H52(CDR-H2) 3.38 -0.68 decreased affinity
350 H Y 52 I H52(CDR-H2) 3.38 -0.89 decreased affinity
351 H Y 52 K H52(CDR-H2) 3.38 -0.75 decreased affinity
352 H Y 52 L H52(CDR-H2) 3.38 -0.96 decreased affinity
353 H Y 52 M H52(CDR-H2) 3.38 -0.94 decreased affinity
354 H Y 52 N H52(CDR-H2) 3.38 -0.2 decreased affinity
355 H Y 52 P H52(CDR-H2) 3.38 -1.2 decreased affinity
356 H Y 52 Q H52(CDR-H2) 3.38 -0.78 decreased affinity
357 H Y 52 R H52(CDR-H2) 3.38 -0.18 decreased affinity
358 H Y 52 S H52(CDR-H2) 3.38 -0.99 decreased affinity
359 H Y 52 T H52(CDR-H2) 3.38 -0.87 decreased affinity
360 H Y 52 V H52(CDR-H2) 3.38 -0.95 decreased affinity
361 H Y 52 W H52(CDR-H2) 3.38 0.29 increased affinity
362 H D 54 A H54(CDR-H2) 2.64 -0.97 decreased affinity
363 H D 54 C H54(CDR-H2) 2.64 -0.88 decreased affinity
364 H D 54 E H54(CDR-H2) 2.64 -0.73 decreased affinity
365 H D 54 F H54(CDR-H2) 2.64 -0.74 decreased affinity
366 H D 54 G H54(CDR-H2) 2.64 -0.7 decreased affinity
367 H D 54 H H54(CDR-H2) 2.64 -1.02 decreased affinity
368 H D 54 I H54(CDR-H2) 2.64 -0.97 decreased affinity
369 H D 54 K H54(CDR-H2) 2.64 -0.91 decreased affinity
370 H D 54 L H54(CDR-H2) 2.64 -0.92 decreased affinity
371 H D 54 M H54(CDR-H2) 2.64 -1.09 decreased affinity
372 H D 54 N H54(CDR-H2) 2.64 -0.45 decreased affinity
373 H D 54 P H54(CDR-H2) 2.64 -0.91 decreased affinity
374 H D 54 Q H54(CDR-H2) 2.64 -0.89 decreased affinity
375 H D 54 R H54(CDR-H2) 2.64 -1.2 decreased affinity
376 H D 54 S H54(CDR-H2) 2.64 -0.44 decreased affinity
377 H D 54 T H54(CDR-H2) 2.64 -0.81 decreased affinity
378 H D 54 V H54(CDR-H2) 2.64 -0.84 decreased affinity
379 H D 54 W H54(CDR-H2) 2.64 -0.48 decreased affinity
380 H D 54 Y H54(CDR-H2) 2.64 -0.74 decreased affinity
381 H D 56 A H56(CDR-H2) 3.21 -1.04 decreased affinity
382 H D 56 C H56(CDR-H2) 3.21 -1.25 decreased affinity
383 H D 56 E H56(CDR-H2) 3.21 -0.89 decreased affinity
384 H D 56 F H56(CDR-H2) 3.21 -1.04 decreased affinity
385 H D 56 G H56(CDR-H2) 3.21 -1.14 decreased affinity
386 H D 56 H H56(CDR-H2) 3.21 -0.96 decreased affinity
387 H D 56 I H56(CDR-H2) 3.21 -1.09 decreased affinity
388 H D 56 K H56(CDR-H2) 3.21 -1.22 decreased affinity
389 H D 56 L H56(CDR-H2) 3.21 -1.09 decreased affinity
390 H D 56 M H56(CDR-H2) 3.21 -1.15 decreased affinity
391 H D 56 N H56(CDR-H2) 3.21 -0.8 decreased affinity
392 H D 56 P H56(CDR-H2) 3.21 -1.02 decreased affinity
393 H D 56 Q H56(CDR-H2) 3.21 -1.1 decreased affinity
394 H D 56 R H56(CDR-H2) 3.21 -1.31 decreased affinity
395 H D 56 S H56(CDR-H2) 3.21 -0.71 decreased affinity
396 H D 56 T H56(CDR-H2) 3.21 -0.7 decreased affinity
397 H D 56 V H56(CDR-H2) 3.21 -1.1 decreased affinity
398 H D 56 W H56(CDR-H2) 3.21 -0.96 decreased affinity
399 H D 56 Y H56(CDR-H2) 3.21 -0.66 decreased affinity
400 H R 58 A H58(HFR3) 2.73 -1.81 decreased affinity
401 H R 58 C H58(HFR3) 2.73 -1.78 decreased affinity
402 H R 58 D H58(HFR3) 2.73 -1.48 decreased affinity
403 H R 58 E H58(HFR3) 2.73 -1.53 decreased affinity
404 H R 58 F H58(HFR3) 2.73 -1.38 decreased affinity
405 H R 58 G H58(HFR3) 2.73 -1.84 decreased affinity
406 H R 58 H H58(HFR3) 2.73 -1.25 decreased affinity
407 H R 58 I H58(HFR3) 2.73 -1.67 decreased affinity
408 H R 58 K H58(HFR3) 2.73 -1.42 decreased affinity
409 H R 58 L H58(HFR3) 2.73 -1.42 decreased affinity
410 H R 58 M H58(HFR3) 2.73 -1.7 decreased affinity
411 H R 58 N H58(HFR3) 2.73 -0.95 decreased affinity
412 H R 58 P H58(HFR3) 2.73 -1.59 decreased affinity
413 H R 58 Q H58(HFR3) 2.73 -1.27 decreased affinity
414 H R 58 S H58(HFR3) 2.73 -1.69 decreased affinity
415 H R 58 T H58(HFR3) 2.73 -1.54 decreased affinity
416 H R 58 V H58(HFR3) 2.73 -1.71 decreased affinity
417 H R 58 W H58(HFR3) 2.73 -1.31 decreased affinity
418 H R 58 Y H58(HFR3) 2.73 -0.66 decreased affinity
419 H R 97 A H97(CDR-H3) 3.13 -1.56 decreased affinity
420 H R 97 C H97(CDR-H3) 3.13 -1.54 decreased affinity
421 H R 97 D H97(CDR-H3) 3.13 -0.8 decreased affinity
422 H R 97 E H97(CDR-H3) 3.13 -1.11 decreased affinity
423 H R 97 F H97(CDR-H3) 3.13 -0.8 decreased affinity
424 H R 97 G H97(CDR-H3) 3.13 -1.32 decreased affinity
425 H R 97 H H97(CDR-H3) 3.13 -1.41 decreased affinity
426 H R 97 I H97(CDR-H3) 3.13 -1.38 decreased affinity
427 H R 97 K H97(CDR-H3) 3.13 -1.24 decreased affinity
428 H R 97 L H97(CDR-H3) 3.13 -1.56 decreased affinity
429 H R 97 M H97(CDR-H3) 3.13 -1.25 decreased affinity
430 H R 97 N H97(CDR-H3) 3.13 -1.22 decreased affinity
431 H R 97 P H97(CDR-H3) 3.13 -1.18 decreased affinity
432 H R 97 Q H97(CDR-H3) 3.13 -1.15 decreased affinity
433 H R 97 S H97(CDR-H3) 3.13 -1.55 decreased affinity
434 H R 97 T H97(CDR-H3) 3.13 -1.32 decreased affinity
435 H R 97 V H97(CDR-H3) 3.13 -1.37 decreased affinity
436 H R 97 W H97(CDR-H3) 3.13 -1.28 decreased affinity
437 H R 97 Y H97(CDR-H3) 3.13 -0.41 decreased affinity
438 H S 99 A H99(CDR-H3) 2.66 -0.25 decreased affinity
439 H S 99 C H99(CDR-H3) 2.66 -0.42 decreased affinity
440 H S 99 D H99(CDR-H3) 2.66 0.31 increased affinity
441 H S 99 E H99(CDR-H3) 2.66 -0.1 decreased affinity
442 H S 99 F H99(CDR-H3) 2.66 -0.39 decreased affinity
443 H S 99 G H99(CDR-H3) 2.66 -0.21 decreased affinity
444 H S 99 H H99(CDR-H3) 2.66 -0.15 decreased affinity
445 H S 99 I H99(CDR-H3) 2.66 -0.4 decreased affinity
446 H S 99 K H99(CDR-H3) 2.66 -0.16 decreased affinity
447 H S 99 L H99(CDR-H3) 2.66 -0.27 decreased affinity
448 H S 99 M H99(CDR-H3) 2.66 -0.46 decreased affinity
449 H S 99 N H99(CDR-H3) 2.66 0.03 increased affinity
450 H S 99 P H99(CDR-H3) 2.66 -0.62 decreased affinity
451 H S 99 Q H99(CDR-H3) 2.66 -0.25 decreased affinity
452 H S 99 R H99(CDR-H3) 2.66 -0.23 decreased affinity
453 H S 99 T H99(CDR-H3) 2.66 -0.32 decreased affinity
454 H S 99 V H99(CDR-H3) 2.66 -0.29 decreased affinity
455 H S 99 W H99(CDR-H3) 2.66 0.6 increased affinity
456 H S 99 Y H99(CDR-H3) 2.66 -0.08 decreased affinity
457 L Q 27 A L27(CDR-L1) 5.92 -0.13 decreased affinity
458 L Q 27 C L27(CDR-L1) 5.92 -0.32 decreased affinity
459 L Q 27 D L27(CDR-L1) 5.92 0.03 increased affinity
460 L Q 27 E L27(CDR-L1) 5.92 0.01 increased affinity
461 L Q 27 F L27(CDR-L1) 5.92 -0.07 decreased affinity
462 L Q 27 G L27(CDR-L1) 5.92 -0.18 decreased affinity
463 L Q 27 H L27(CDR-L1) 5.92 -0.1 decreased affinity
464 L Q 27 I L27(CDR-L1) 5.92 -0.07 decreased affinity
465 L Q 27 K L27(CDR-L1) 5.92 -0.15 decreased affinity
466 L Q 27 L L27(CDR-L1) 5.92 -0.08 decreased affinity
467 L Q 27 M L27(CDR-L1) 5.92 -0.22 decreased affinity
468 L Q 27 N L27(CDR-L1) 5.92 -0.04 decreased affinity
469 L Q 27 P L27(CDR-L1) 5.92 -0.07 decreased affinity
470 L Q 27 R L27(CDR-L1) 5.92 -0.17 decreased affinity
471 L Q 27 S L27(CDR-L1) 5.92 -0.08 decreased affinity
472 L Q 27 T L27(CDR-L1) 5.92 -0.05 decreased affinity
473 L Q 27 V L27(CDR-L1) 5.92 -0.07 decreased affinity
474 L Q 27 W L27(CDR-L1) 5.92 -0.14 decreased affinity
475 L Q 27 Y L27(CDR-L1) 5.92 -0.1 decreased affinity
476 L Y 27D A L30A(CDR-L1) 3.36 -1.06 decreased affinity
477 L Y 27D C L30A(CDR-L1) 3.36 -0.67 decreased affinity
478 L Y 27D D L30A(CDR-L1) 3.36 -0.5 decreased affinity
479 L Y 27D E L30A(CDR-L1) 3.36 -0.43 decreased affinity
480 L Y 27D F L30A(CDR-L1) 3.36 -0.08 decreased affinity
481 L Y 27D G L30A(CDR-L1) 3.36 -1.2 decreased affinity
482 L Y 27D H L30A(CDR-L1) 3.36 -0.09 decreased affinity
483 L Y 27D I L30A(CDR-L1) 3.36 -0.51 decreased affinity
484 L Y 27D K L30A(CDR-L1) 3.36 -0.49 decreased affinity
485 L Y 27D L L30A(CDR-L1) 3.36 -0.63 decreased affinity
486 L Y 27D M L30A(CDR-L1) 3.36 -0.63 decreased affinity
487 L Y 27D N L30A(CDR-L1) 3.36 -0.4 decreased affinity
488 L Y 27D P L30A(CDR-L1) 3.36 -0.88 decreased affinity
489 L Y 27D Q L30A(CDR-L1) 3.36 -0.49 decreased affinity
490 L Y 27D R L30A(CDR-L1) 3.36 -0.25 decreased affinity
491 L Y 27D S L30A(CDR-L1) 3.36 -0.54 decreased affinity
492 L Y 27D T L30A(CDR-L1) 3.36 -0.56 decreased affinity
493 L Y 27D V L30A(CDR-L1) 3.36 -0.74 decreased affinity
494 L Y 27D W L30A(CDR-L1) 3.36 0.07 increased affinity
495 L S 27E A L30B(CDR-L1) 5.39 -0.0 decreased affinity
496 L S 27E C L30B(CDR-L1) 5.39 -0.23 decreased affinity
497 L S 27E D L30B(CDR-L1) 5.39 0.05 increased affinity
498 L S 27E E L30B(CDR-L1) 5.39 0.08 increased affinity
499 L S 27E F L30B(CDR-L1) 5.39 -0.08 decreased affinity
500 L S 27E G L30B(CDR-L1) 5.39 0.0 increased affinity
501 L S 27E H L30B(CDR-L1) 5.39 -0.14 decreased affinity
502 L S 27E I L30B(CDR-L1) 5.39 -0.04 decreased affinity
503 L S 27E K L30B(CDR-L1) 5.39 0.0 increased affinity
504 L S 27E L L30B(CDR-L1) 5.39 -0.03 decreased affinity
505 L S 27E M L30B(CDR-L1) 5.39 -0.22 decreased affinity
506 L S 27E N L30B(CDR-L1) 5.39 0.05 increased affinity
507 L S 27E P L30B(CDR-L1) 5.39 0.03 increased affinity
508 L S 27E Q L30B(CDR-L1) 5.39 0.02 increased affinity
509 L S 27E R L30B(CDR-L1) 5.39 -0.05 decreased affinity
510 L S 27E T L30B(CDR-L1) 5.39 0.02 increased affinity
511 L S 27E V L30B(CDR-L1) 5.39 -0.02 decreased affinity
512 L S 27E W L30B(CDR-L1) 5.39 -0.04 decreased affinity
513 L S 27E Y L30B(CDR-L1) 5.39 -0.07 decreased affinity
514 L N 28 A L30D(CDR-L1) 4.37 -0.4 decreased affinity
515 L N 28 C L30D(CDR-L1) 4.37 -0.56 decreased affinity
516 L N 28 D L30D(CDR-L1) 4.37 -0.03 decreased affinity
517 L N 28 E L30D(CDR-L1) 4.37 -0.32 decreased affinity
518 L N 28 F L30D(CDR-L1) 4.37 -0.4 decreased affinity
519 L N 28 G L30D(CDR-L1) 4.37 -0.51 decreased affinity
520 L N 28 H L30D(CDR-L1) 4.37 -0.54 decreased affinity
521 L N 28 I L30D(CDR-L1) 4.37 -0.35 decreased affinity
522 L N 28 K L30D(CDR-L1) 4.37 -0.12 decreased affinity
523 L N 28 L L30D(CDR-L1) 4.37 -0.3 decreased affinity
524 L N 28 M L30D(CDR-L1) 4.37 -0.55 decreased affinity
525 L N 28 P L30D(CDR-L1) 4.37 -0.47 decreased affinity
526 L N 28 Q L30D(CDR-L1) 4.37 -0.33 decreased affinity
527 L N 28 R L30D(CDR-L1) 4.37 -0.51 decreased affinity
528 L N 28 S L30D(CDR-L1) 4.37 -0.34 decreased affinity
529 L N 28 T L30D(CDR-L1) 4.37 -0.44 decreased affinity
530 L N 28 V L30D(CDR-L1) 4.37 -0.38 decreased affinity
531 L N 28 W L30D(CDR-L1) 4.37 -0.39 decreased affinity
532 L N 28 Y L30D(CDR-L1) 4.37 -0.4 decreased affinity
533 L K 30 A L30F(CDR-L1) 5.6 -0.42 decreased affinity
534 L K 30 C L30F(CDR-L1) 5.6 -0.47 decreased affinity
535 L K 30 D L30F(CDR-L1) 5.6 -0.03 decreased affinity
536 L K 30 E L30F(CDR-L1) 5.6 0.03 increased affinity
537 L K 30 F L30F(CDR-L1) 5.6 -0.11 decreased affinity
538 L K 30 G L30F(CDR-L1) 5.6 -0.48 decreased affinity
539 L K 30 H L30F(CDR-L1) 5.6 0.03 increased affinity
540 L K 30 I L30F(CDR-L1) 5.6 -0.06 decreased affinity
541 L K 30 L L30F(CDR-L1) 5.6 -0.06 decreased affinity
542 L K 30 M L30F(CDR-L1) 5.6 -0.72 decreased affinity
543 L K 30 N L30F(CDR-L1) 5.6 0.03 increased affinity
544 L K 30 P L30F(CDR-L1) 5.6 -0.56 decreased affinity
545 L K 30 Q L30F(CDR-L1) 5.6 0.04 increased affinity
546 L K 30 R L30F(CDR-L1) 5.6 -0.1 decreased affinity
547 L K 30 S L30F(CDR-L1) 5.6 -0.09 decreased affinity
548 L K 30 T L30F(CDR-L1) 5.6 -0.31 decreased affinity
549 L K 30 V L30F(CDR-L1) 5.6 -0.33 decreased affinity
550 L K 30 W L30F(CDR-L1) 5.6 -0.06 decreased affinity
551 L K 30 Y L30F(CDR-L1) 5.6 -0.04 decreased affinity
552 L Y 32 A L32(CDR-L1) 2.45 -2.9 decreased affinity
553 L Y 32 C L32(CDR-L1) 2.45 -2.52 decreased affinity
554 L Y 32 D L32(CDR-L1) 2.45 -2.29 decreased affinity
555 L Y 32 E L32(CDR-L1) 2.45 -1.9 decreased affinity
556 L Y 32 F L32(CDR-L1) 2.45 -1.21 decreased affinity
557 L Y 32 G L32(CDR-L1) 2.45 -2.86 decreased affinity
558 L Y 32 H L32(CDR-L1) 2.45 -1.55 decreased affinity
559 L Y 32 I L32(CDR-L1) 2.45 -2.52 decreased affinity
560 L Y 32 K L32(CDR-L1) 2.45 -2.25 decreased affinity
561 L Y 32 L L32(CDR-L1) 2.45 -2.45 decreased affinity
562 L Y 32 M L32(CDR-L1) 2.45 -2.53 decreased affinity
563 L Y 32 N L32(CDR-L1) 2.45 -1.82 decreased affinity
564 L Y 32 P L32(CDR-L1) 2.45 -2.67 decreased affinity
565 L Y 32 Q L32(CDR-L1) 2.45 -1.86 decreased affinity
566 L Y 32 R L32(CDR-L1) 2.45 -0.33 decreased affinity
567 L Y 32 S L32(CDR-L1) 2.45 -2.37 decreased affinity
568 L Y 32 T L32(CDR-L1) 2.45 -2.2 decreased affinity
569 L Y 32 V L32(CDR-L1) 2.45 -2.62 decreased affinity
570 L Y 32 W L32(CDR-L1) 2.45 -0.14 decreased affinity
571 L W 50 A L50(CDR-L2) 3.79 -1.3 decreased affinity
572 L W 50 C L50(CDR-L2) 3.79 -1.32 decreased affinity
573 L W 50 D L50(CDR-L2) 3.79 -0.76 decreased affinity
574 L W 50 E L50(CDR-L2) 3.79 -0.45 decreased affinity
575 L W 50 F L50(CDR-L2) 3.79 -0.79 decreased affinity
576 L W 50 G L50(CDR-L2) 3.79 -1.08 decreased affinity
577 L W 50 H L50(CDR-L2) 3.79 -0.76 decreased affinity
578 L W 50 I L50(CDR-L2) 3.79 -1.16 decreased affinity
579 L W 50 K L50(CDR-L2) 3.79 -0.85 decreased affinity
580 L W 50 L L50(CDR-L2) 3.79 -1.1 decreased affinity
581 L W 50 M L50(CDR-L2) 3.79 -1.21 decreased affinity
582 L W 50 N L50(CDR-L2) 3.79 -0.89 decreased affinity
583 L W 50 P L50(CDR-L2) 3.79 -1.15 decreased affinity
584 L W 50 Q L50(CDR-L2) 3.79 -0.98 decreased affinity
585 L W 50 R L50(CDR-L2) 3.79 -0.59 decreased affinity
586 L W 50 S L50(CDR-L2) 3.79 -0.93 decreased affinity
587 L W 50 T L50(CDR-L2) 3.79 -1.03 decreased affinity
588 L W 50 V L50(CDR-L2) 3.79 -1.19 decreased affinity
589 L W 50 Y L50(CDR-L2) 3.79 -0.3 decreased affinity
590 L Y 91 A L91(CDR-L3) 2.64 -3.21 decreased affinity
591 L Y 91 C L91(CDR-L3) 2.64 -2.75 decreased affinity
592 L Y 91 D L91(CDR-L3) 2.64 -2.01 decreased affinity
593 L Y 91 E L91(CDR-L3) 2.64 -2.01 decreased affinity
594 L Y 91 F L91(CDR-L3) 2.64 -0.83 decreased affinity
595 L Y 91 G L91(CDR-L3) 2.64 -3.21 decreased affinity
596 L Y 91 H L91(CDR-L3) 2.64 -1.07 decreased affinity
597 L Y 91 I L91(CDR-L3) 2.64 -2.91 decreased affinity
598 L Y 91 K L91(CDR-L3) 2.64 -1.95 decreased affinity
599 L Y 91 L L91(CDR-L3) 2.64 -2.86 decreased affinity
600 L Y 91 M L91(CDR-L3) 2.64 -2.77 decreased affinity
601 L Y 91 N L91(CDR-L3) 2.64 -1.34 decreased affinity
602 L Y 91 P L91(CDR-L3) 2.64 -3.21 decreased affinity
603 L Y 91 Q L91(CDR-L3) 2.64 -1.72 decreased affinity
604 L Y 91 R L91(CDR-L3) 2.64 0.22 increased affinity
605 L Y 91 S L91(CDR-L3) 2.64 -2.63 decreased affinity
606 L Y 91 T L91(CDR-L3) 2.64 -2.73 decreased affinity
607 L Y 91 V L91(CDR-L3) 2.64 -3.06 decreased affinity
608 L Y 91 W L91(CDR-L3) 2.64 1.22 increased affinity
609 L Y 92 A L92(CDR-L3) 2.8 -2.06 decreased affinity
610 L Y 92 C L92(CDR-L3) 2.8 -1.86 decreased affinity
611 L Y 92 D L92(CDR-L3) 2.8 -1.6 decreased affinity
612 L Y 92 E L92(CDR-L3) 2.8 -1.54 decreased affinity
613 L Y 92 F L92(CDR-L3) 2.8 -1.14 decreased affinity
614 L Y 92 G L92(CDR-L3) 2.8 -2.04 decreased affinity
615 L Y 92 H L92(CDR-L3) 2.8 -1.14 decreased affinity
616 L Y 92 I L92(CDR-L3) 2.8 -1.86 decreased affinity
617 L Y 92 K L92(CDR-L3) 2.8 -1.44 decreased affinity
618 L Y 92 L L92(CDR-L3) 2.8 -1.78 decreased affinity
619 L Y 92 M L92(CDR-L3) 2.8 -1.86 decreased affinity
620 L Y 92 N L92(CDR-L3) 2.8 -1.16 decreased affinity
621 L Y 92 P L92(CDR-L3) 2.8 -1.98 decreased affinity
622 L Y 92 Q L92(CDR-L3) 2.8 -1.23 decreased affinity
623 L Y 92 R L92(CDR-L3) 2.8 -0.04 decreased affinity
624 L Y 92 S L92(CDR-L3) 2.8 -1.84 decreased affinity
625 L Y 92 T L92(CDR-L3) 2.8 -1.72 decreased affinity
626 L Y 92 V L92(CDR-L3) 2.8 -1.93 decreased affinity
627 L Y 92 W L92(CDR-L3) 2.8 0.72 increased affinity
628 L N 93 A L93(CDR-L3) 2.83 -0.73 decreased affinity
629 L N 93 C L93(CDR-L3) 2.83 -0.81 decreased affinity
630 L N 93 D L93(CDR-L3) 2.83 0.11 increased affinity
631 L N 93 E L93(CDR-L3) 2.83 -0.42 decreased affinity
632 L N 93 F L93(CDR-L3) 2.83 -0.61 decreased affinity
633 L N 93 G L93(CDR-L3) 2.83 -0.87 decreased affinity
634 L N 93 H L93(CDR-L3) 2.83 -0.22 decreased affinity
635 L N 93 I L93(CDR-L3) 2.83 -0.59 decreased affinity
636 L N 93 K L93(CDR-L3) 2.83 -0.48 decreased affinity
637 L N 93 L L93(CDR-L3) 2.83 -0.69 decreased affinity
638 L N 93 M L93(CDR-L3) 2.83 -0.98 decreased affinity
639 L N 93 P L93(CDR-L3) 2.83 -0.52 decreased affinity
640 L N 93 Q L93(CDR-L3) 2.83 -0.47 decreased affinity
641 L N 93 R L93(CDR-L3) 2.83 -0.48 decreased affinity
642 L N 93 S L93(CDR-L3) 2.83 -0.15 decreased affinity
643 L N 93 T L93(CDR-L3) 2.83 -0.25 decreased affinity
644 L N 93 V L93(CDR-L3) 2.83 -0.62 decreased affinity
645 L N 93 W L93(CDR-L3) 2.83 -0.45 decreased affinity
646 L N 93 Y L93(CDR-L3) 2.83 -0.6 decreased affinity
647 L S 94 A L94(CDR-L3) 3.62 -0.2 decreased affinity
648 L S 94 C L94(CDR-L3) 3.62 -0.32 decreased affinity
649 L S 94 D L94(CDR-L3) 3.62 -0.09 decreased affinity
650 L S 94 E L94(CDR-L3) 3.62 -0.08 decreased affinity
651 L S 94 F L94(CDR-L3) 3.62 0.49 increased affinity
652 L S 94 G L94(CDR-L3) 3.62 -0.55 decreased affinity
653 L S 94 H L94(CDR-L3) 3.62 0.15 increased affinity
654 L S 94 I L94(CDR-L3) 3.62 0.12 increased affinity
655 L S 94 K L94(CDR-L3) 3.62 0.72 increased affinity
656 L S 94 L L94(CDR-L3) 3.62 -0.18 decreased affinity
657 L S 94 M L94(CDR-L3) 3.62 -0.54 decreased affinity
658 L S 94 N L94(CDR-L3) 3.62 0.26 increased affinity
659 L S 94 P L94(CDR-L3) 3.62 -0.22 decreased affinity
660 L S 94 Q L94(CDR-L3) 3.62 0.22 increased affinity
661 L S 94 R L94(CDR-L3) 3.62 1.16 increased affinity
662 L S 94 T L94(CDR-L3) 3.62 -0.07 decreased affinity
663 L S 94 V L94(CDR-L3) 3.62 -0.14 decreased affinity
664 L S 94 W L94(CDR-L3) 3.62 1.18 increased affinity
665 L S 94 Y L94(CDR-L3) 3.62 0.36 increased affinity
666 L Y 96 A L96(CDR-L3) 2.32 -2.59 decreased affinity
667 L Y 96 C L96(CDR-L3) 2.32 -2.24 decreased affinity
668 L Y 96 D L96(CDR-L3) 2.32 -2.01 decreased affinity
669 L Y 96 E L96(CDR-L3) 2.32 -1.48 decreased affinity
670 L Y 96 F L96(CDR-L3) 2.32 -0.43 decreased affinity
671 L Y 96 G L96(CDR-L3) 2.32 -2.66 decreased affinity
672 L Y 96 H L96(CDR-L3) 2.32 -1.2 decreased affinity
673 L Y 96 I L96(CDR-L3) 2.32 -2.19 decreased affinity
674 L Y 96 K L96(CDR-L3) 2.32 -1.5 decreased affinity
675 L Y 96 L L96(CDR-L3) 2.32 -1.97 decreased affinity
676 L Y 96 M L96(CDR-L3) 2.32 -2.12 decreased affinity
677 L Y 96 N L96(CDR-L3) 2.32 -1.71 decreased affinity
678 L Y 96 P L96(CDR-L3) 2.32 -2.4 decreased affinity
679 L Y 96 Q L96(CDR-L3) 2.32 -1.57 decreased affinity
680 L Y 96 R L96(CDR-L3) 2.32 0.43 increased affinity
681 L Y 96 S L96(CDR-L3) 2.32 -2.14 decreased affinity
682 L Y 96 T L96(CDR-L3) 2.32 -2.04 decreased affinity
683 L Y 96 V L96(CDR-L3) 2.32 -2.39 decreased affinity
684 L Y 96 W L96(CDR-L3) 2.32 1.08 increased affinity

Visualisation

HeatMap

Sequence Viewer

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LIGHT CHAIN
HEAVY CHAIN

Download

Result(csv) file
PDB file (colored by averaged ΔΔG)